Beta-Defensin 126 on the Cell Surface Protects Sperm from Immunorecognition and Binding of Anti-Sperm Antibodies1
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چکیده
منابع مشابه
Comparison of the Effect of Alpha Lipoic Acid (ALA) and Beta-Defensin 1 Protein on Human Sperm Motility and Viability in Different Times of Incubation
Background and Objectives: Antioxidant alpha lipoic acid and β-defensin 1 protein may have a positive effect on the quality of sperm parameters. In this study, the effect of sperm incubation with alpha lipoic acid antioxidant and β-defensin 1 protein were assessed on sperm motility and viability at different times. Methods: In this experimental study, routine semen analysis was carried out o...
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Background: Paclitaxel (Taxol, TXL) is a chemotherapy agent which widely used in the treatment of tumors, such as lung cancer, breast and prostatic cancer. Previous reports indicate that taxol damages mainly dividing cells (spermatogonias and spermatocytes) and postmeiotic epitheliocytes (spermatids and spermatozoa). The toxic effect of the drug on microtubules underlies its antiproliferative e...
متن کاملTargeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding.
During epididymal maturation, sperm acquire the ability to swim progressively by interacting with proteins secreted by the epididymal epithelium. Beta-defensin proteins, expressed in the epididymis, continue to regulate sperm motility during capacitation and hyperactivation in the female reproductive tract. We characterized the mouse beta-defensin 41 (DEFB41), by generating a mouse model with i...
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Sperm surface beta 1,4-galactosyltransferase (GalTase) mediates fertilization in mice by binding to specific O-linked oligosaccharide ligands on the egg coat glycoprotein ZP3. Before binding the egg, sperm GalTase is masked by epididymally derived glycosides that are shed from the sperm surface during capacitation. After binding the egg, sperm-bound oligosaccharides on ZP3 induce the acrosome r...
متن کاملDiversity of the inhibitory effects on fertilization by anti-sperm antibodies bound to the surface of ejaculated human sperm.
BACKGROUND The presence of anti-sperm antibodies (ASA) in males can reduce fecundity. However, it has been shown that there is a diversity of ASA bound to the sperm surface. This study was performed to investigate the inhibitory effects on fertilization by ASA in males. METHODS ASA were detected using the direct-immunobead test (D-IBT) in 509 semen samples. In some cases, the direct-sperm imm...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2005
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.105.042432